APLICACIÓN CÉLULAS MADRE

Otro trabajo aceptado para presentar en Stem cell congress

INTRACAVERNOUS ADMINISTRATION OF ADIPOSE STEM CELLS: A NEW TECHNIQUE OF TREATING ERECTILE DYSFUNCTION, PRELIMINARY REPORT OF 6 CASE

Author Block: Garber, Miguel G., Diuana, Carlos N. Medicina Regenerativa, Clinica Quirurgica Quantum, Madrid, Spain

Abstract:

OBJECTIVES: After revolutionized treatment of ED with PDE5 inhibitors, approximately 30% of patients are non-responsive. A important cause of this is vascular and smooth muscle dysfunction, as well as nerve atrophy. Stem cells are characterized by multipotent differentiation, and stimulation of angiogenesis/regeneration. . We report the effects of intracavernosal application of adipose stem cells (ASC) on diabetic erectile dysfunction.

MATERIALS AND METHODS: Five type 2 diabetics who had failed to achieve an erection for at least 6 months despite medications, and who are currently awaiting penile prostheses, participated in this study. All laboratory results were normal, except for erectly dysfunction and diabetes mellitus. A total of 1.5 x 10(7) adipose stem cells was infused into the corpus cavernosum. No immunosuppressive measures were taken in any of the patients. International index of erectile function-5, Encounter Profile Question 3 (SEP3), GAQ, erection diary, blood glucose diary, and medication dosage were followed for 6 months. RESULTS: The mean age was 67.3 years (range, 53-80 years). Morning erections were recovered in 4 participants within 2 month, and for all except 1 by the 95 days, and maintained for more than 3 months. Rigidity increased as the result of stem cell therapy alone, but was insufficient for penetration. With the addition of PDE5 inhibitor before coitus, 3 achieved penetration and experienced orgasm, and maintained for more than 4 months. All but 1 reported increased desire. During follow-up, 2 returned for prosthesis, 4 returned to a nonerectile condition at 7 months, and 2 maintained erection sufficient for coitus with medication until the 9th month. Blood glucose levels decreased by 2 weeks, and medication dosages were reduced in all for 4 to 7 months. Glycosylated hemoglobin levels improved after treatment.

CONCLUSIONS: Human adipose stem cell therapy has positive effects on erectile dysfunction in diabetes mellitus patients. Stem cells mediate mechanism may contribute to these positive effects. Travel Grant Justification:

Abstract Submission Topic (Complete): Epithelial and Mesenchymal Stem Cells ; Diabetes Secondary Submission Topic (Complete): *Secondary Topic: Pre-clinical and Clinical Applications of Mesenchymal Cells