APLICACIÓN CÉLULAS MADRE
Spinal cord injury (SCI) is a devastating condition. It not only creates enormous physical and emotional cost to the victims but also causes a financial burden to the society at large. The treatment of SCI focuses on preventing further injury and enabling people to return to an active and productive life within limits of their disability. Recently there is great excitement about the possibility of generating neural progenitor cells from sources such as mesenchymal cells derived from skin, bone-marrow, or adipose tissue. Stem cell therapy in traumatic spinal cord injury is an on going area of research in many centres in India and abroad. We describe a case of traumatic spinal cord injury with complete paraplegia in an adult where we had infused autologous bone marrow derived stem cell to damaged cord during fixation procedure and review the literature.
Spinal cord injury (SCI) is a devastating condition, and creates enormous physical and emotional cost to the victims but also causes a financial burden to the society at large. The treatment of SCI focuses on preventing further injury and enabling people to return to an active and productive life within limits of their disability. Most stem cell-based therapeutic procedures are investigational and still require preclinical and clinical studies to support their many novel therapeutic uses. Medical researchers believe that stem cell therapy has the potential to dramatically change the treatment of human disease. A number of adult stem cell therapies already exist. Recently there is great excitement about the possibility of generating neural progenitor cells from sources such as mesenchymal cells derived from skin, bone-marrow, or adipose tissue. Stem cell therapy in traumatic spinal cord injury is an on going area of research in many centres abroad the word. We describe a case of traumatic spinal cord injury with complete paraplegia in an adult where we had infused autologous adipose derived stem cell to damaged cord 18 months after fixation procedure. There had been no improvement in her neurological function for the past 18 months. Adipose-derived mesenchymal stem cells were retrieved from her infra-umbilical fat, harvesting by mini lipoaspiration. After obtained the adipose tissue, it is processed to obtained the Stromal Vascular Fraction (SVF) and was applied intra-spinal cord at level of the lesion, and the intrathecal space between L4 and L5. After cell transplantation patient continuum with physical therapy in spine lesion center. 48 hours after the transplantation, she presented with a minimal lower extremity motion, at two months she was able to move and keep moving lower extremities, 6 months later patient can stand up and walk with tutors and walker.
