APLICACIÓN CÉLULAS MADRE

Few areas of science have generated as much public interest as Stem cell research, its remains an exploding area of investigation with the potential to change human health. Advances in stem cell medicine promise novel, cell-based therapies for many diseases in which conventional medicine is ineffective. Our mission to promote good science and responsible clinical translation has never been as important as it is today. In 2002, researchers at UCLA published a manuscript in Molecular Biology of the Cell relating a novel adult stem cell population isolated from adipose tissue called the adipose-derived stem cell (ASC). Since that time, the ASC has gone on to be one of the most popular adult stem cell populations currently being used in the stem cell field, and adipose tissue is not longer considered an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions called Stromal Vascular Fraction. Adipose tissue represents an abundant and accessible source of multipotent adult stem cells and is used by many investigators for tissue engineering applications; Several scientific studies demonstrate the potential of adipose adult stem cells in regenerative medicine. Similar to other stem cell populations, it was initially thought that the main potential of ASCs for regenerative medicine approaches was intimately related to their differentiation capability. Although this is true, there has been an increasing body of literature describing the trophic effects of ASCs on the protection, survival and differentiation of a variety of endogenous cells/tissues. Moreover, they have also shown to possess an immunomodulatory character. This effect is closely related to the ASCs' secretome and the soluble factors found within it. Molecules such as hepatocyte growth factor (HGF), granulocyte and macrophage colony stimulating factors, interleukins (ILs) 6, 7, 8 and 11, tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), adipokines and others have been identified within the ASCs' secretome.


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